Tottenham have been drawn against Anzhi Makhachkala and Swansea City will face Valencia in the Europa League group stage.
Spurs -- who reached last season's quarter-final stage, where they lost out to Basel -- will also face Sheriff Tiraspol of Moldova and Tromso of Norway in Group K.
The big-spending London side are preparing for life without star player Gareth Bale -- who is expected to join Real Madrid for a world-record transfer fee before the end of the summer transfer window -- but will still be seen as one of the favourites to lift the trophy won by Chelsea last season after entering the draw as one of the top seeds.
Valencia and Swansea are joined in Group A by Russia’s Kuban Krasnodar and St Gallen of Switzerland.
The trip to Valencia will see Swansea's Spain international midfielder Pablo Hernandez return to his former club. Manager Michael Laudrup -- who led the Swans into Europe via their Capital One Cup triumph last term -- and several of his other players will also familiar to Spanish football fans.
"There are good quality teams," Valencia coach Miroslav Djukic said. "There is no weak one. Plus this is a nice competition, which we are approaching with the greatest of excitement and the highest aspirations.
"We believe we have a strong enough team to beat anyone in the competition, but we are not going to be taking on any team which would allow us to relax even a little in any game."
Djukic is happy to taking on Swansea, given their La Liga influence.
"Their style will be better for us because they play and let you play," he added. "That can make for nice games which are attractive for the fans."
Valencia president Amadeo Salvo is excited to be facing former Che stars Hernandez and Angel Dealbert, who now plays for Kuban Krasnodar.
"It is a difficult group, but attractive for the fans, as players like Pablo Hernandez and Angel Dealbert -- two great valencianistas from our recent history -- are returning to Mestalla," Salvo said. "It is good news to know they are returning."
Group D contains FA Cup winners Wigan Athletic -- since relegated to the Championship -- along with Rubin Kazan, Maribor and Zulte Waregem.
In Group H, Sevilla -- who enjoyed back-to-back triumphs in the Europa League's forerunner, the UEFA Cup, in 2006 and 2007 -- take on Bundesliga side Freiburg plus Estoril and Liberec of Portugal and the Czech Republic respectively.
French side Lyon, beaten by Real Sociedad in the Champions League play-off, take on another Spanish side, Real Betis, in Group I, along with Portugal's Vitoria de Guimaraes and Croatia's Rijeka.