Brian McDermott has left his post as manager of Reading, the club confirmed in a statement Monday.
The Royals lost four successive Barclays Premier League games and sit 19th in the table, with only goals scored keeping them off the bottom.
McDermott, 51, took over as caretaker manager at the Madejski Stadium in 2009 before being named full-time boss the following year.
He guided Reading back to the top flight last season for only the second time in their history but has been relieved of his duties as the club look to turn around their form in time to secure Premier League survival.
McDermott has been part of the backroom staff at the Berkshire club since 2000, fulfilling a number of roles before taking the manager's position full-time in January 2010.
Reading issued a statement confirming McDermott's departure with Russian owner Anton Zingarevich believing having a new man in charge was essential.
"Reading Football Club has announced today the departure of manager Brian McDermott," the statement read. "Owner Anton Zingarevich wishes to place on record his thanks to Brian who had achieved great success with the club since taking over as manager in December 2009."