Striker Daniel Sturridge is out of England's friendly against Brazil on Wednesday after suffering a thigh injury during Liverpool's 2-2 draw with Manchester City at the Etihad Stadium.
Sturridge, 23, was substituted near the end of a game in which he had played superbly and scored his first goal, and his manager Brendan Rodgers has said it was unlikely that he would be able to face the Brazilians.
"He [Sturridge] got a knock just before half-time on his thigh and he wanted to give it a go in the second half. I think he will be a doubt for the game on Wednesday," Rodgers said.
"He will have a chat with our doctors and he will speak with the England set-up. They might want to have a look at it, but at the moment he is obviously struggling.''
His withdrawal is a third setback in two days for the England coach Roy Hodgson, who has already lost Tottenham's Jermain Defoe and Manchester United's Michael Carrick to injuries.
Although Sturridge reported for duty at St George's Park on Sunday, he was unable to take part in Monday's training session and has returned to Anfield for treatment to his injury.
The news means England's only fit strikers, as things stand, are Manchester United's Wayne Rooney and Danny Welbeck.