Atletico Madrid are in control of their Copa del Rey quarter-final tie with Real Betis after claiming a 2-0 win in the first-leg at the Vicente Calderon on Thursday.
Diego Simeone named a strong side for the clash as Atletico target one of their best chances of silverware this season.
The manager's selections paid dividends when Radamel Falcao opened the scoring for the hosts 11 minutes into the match, heading home a Raul Garcia cross from close range.
Atletico doubled their advantage just 12 minutes later when Luis Filipe finished a tidy shot from inside the penalty area after Betis' poor clearance from Mario Suarez's free kick.
The visitors' slim chances of a comeback lost further momentum either side of half-time with Atletico goalkeeper Thibaut Courtois pulling off a series of outstanding staves to deny Betis.
Although Pepe Mel's side had a fair share of chances in the second half, they face an uphill battle to overturn the two goal deficit in the return match at the Estadio Manuel Ruiz de Lopera on January 24.
Information from the Press Association was used in this report.