"I like what I have seen of Theo through the middle," the Arsenal manager said. "It's an interesting challenge (for him). I think he can take it on. He is now 23. I decided to play Thierry Henry at 23 through the middle because you have to learn a lot before."
Wenger on Friday also reiterated his hope that Walcott will sign a new deal.
The Arsenal boss has imposed a New Year's Day deadline on negotiations, although Wenger has indicated he will not sell Walcott in January even if it means losing him for free in the summer.
Wenger denied that playing Walcott through the middle for the past two matches would help his chances of keeping the player, but he does remain confident of holding on to him.
"No I don't think (playing him as a striker will impact on negotiations)," Wenger said. "I want him to stay and I want him to extend his contract and I have always been consistent on that. Yes (talks are ongoing) and yes I remain optimistic he will sign."
Wenger has acquiesced to Walcott's demands to play a more central role in the last two weeks and the move has paid off handsomely.
The 23-year-old scored in the Gunners' 5-2 victory over Reading and then won the penalty that handed the Gunners their vital win over Wigan last weekend.
Wenger has been reluctant to deploy Walcott as a striker in the past, but he now appears content to give the England international an extended run up front in the hope that he can turn himself in to a clinical finisher in the same way that club record scorer Henry did.
And Wenger thinks the influence of Henry, who has been training at Arsenal's London Colney base in recent weeks, has helped the former Southampton forward adapt to his new role.
"Thierry gives him advice, which is always important and Theo is a very intelligent boy," Wenger said. "He understands very quickly when you tell him something and that's why I think he can do very well in this position."
With Gervinho off to the African Nations Cup next month, Wenger could bid for another striker when the transfer window opens, but he denied being interested in Demba Ba, who can leave Newcastle for $4.64 million.
"I like Demba Ba, yes," the Arsenal manager said ahead of his team's match against the Magpies Saturday. "But if you ask me 'do we sign Demba Ba?' I say no."
A more realistic option for Wenger appears to be re-signing Henry for a second loan spell.
"He is still good enough to play in the Premier League, absolutely," Wenger said. "He is in a better physical shape than he was last time he was here last year."
Wenger said earlier this week that he would not sign Henry again, but appears to have softened that stance.
"I've not lost interest in him," said Wenger, who signed Henry on a temporary deal last January. "I've not completely (ruled a loan move out). But I haven't spoken about it with him at all.
"He's still coming today to practice with us," he added. "We are very close (personally) but at the moment, I think he has had a second spell at the club that was very successful. You have to be cautious that it's not one time too many."
Wenger admitted Friday he will be a busy man when the transfer window opens, not just in his attempt to sign players, but also in his bid at dumping the little-used squad players clogging up his squad.
"I have not had a call from Reading (about Arshavin)," Wenger added. "(But) if he finds a solution that is satisfying for him and for us we will consider it."
Information from Press Association was used in this report.