NYON, Switzerland -- Real Madrid will face Manchester United in the last 16 of the Champions League, a matchup that sends Cristiano Ronaldo back to the stadium where he made his reputation and Jose Mourinho to the club many believe he wants to coach.
Thursday's draw also paired favorite Barcelona and Lionel Messi against seven-time winner AC Milan.
Arsenal will face Bayern Munich, which lost to Chelsea in last season's final, and high-spending Paris Saint-Germain will meet Valencia. Other pairings were Celtic-Juventus, Shakhtar Donetsk-Borussia Dortmund, Porto-Malaga, and Galatasaray-Schalke.
First-leg matches are from Feb. 12-20, with return legs March 5-13.
Madrid, a nine-time champion, hosts three-time winner United on Feb. 13, with the second leg at Old Trafford on March 5.
"It's a great opportunity for our fans to see Cristiano again and also for me to meet up with Jose again," United manager Six Alex Ferguson said in comments posted on the club's official website.
The coaches met in Manchester this month, ahead of Madrid's group match against English champion City, adding to speculation that Mourinho covets the United job.
Mourinho is remembered for his flamboyant victory sprint down the sideline at Old Trafford when his Porto team eliminated United in the second round in 2004, the first of Ronaldo's six seasons in England before joining Madrid. But Mourinho has never won a Champions League game at Old Trafford.
United defender Rio Ferdinand wrote on Twitter: "Oh yes, Madrid!! What a great couple a games that'll be!! @Cristiano see u soon bro!!"
The last time United and Madrid met was in the 2003 Champions League quarterfinals when the Spanish side progressed 6-5 on aggregate. Brazilian striker Ronaldo scored a hat trick in the return leg at Old Trafford.
Milan had the misfortune to draw Barcelona again after being unable to beat the Catalan side in four matches in last season's group stage and quarterfinals. This year's tie will start Feb. 20 at the San Siro and move to Camp Nou March 12.
"They're not pleased. We're not pleased, but this is what the destiny is," Milan director Umberto Gandini said with a smile. "We have to go over the most difficult team on the planet."
Arsenal will play the first leg at the Emirates Stadium on Feb. 19 and the second at the Allianz Arena in Munich on March 13.
Arsenal striker and German international Lukas Podolski sees no reason why Arsenal should not be able to knock his old club Bayern Munich out of the Champions League.
"They played in the final in 2010 and last year. It is a big club, but we have the chance to win against Bayern Munich," Podolski told Arsenal Player. "They have (Mario) Gomez up front, they have (Franck) Ribery, (Bastian) Schweinsteiger, Philipp Lahm, Manuel Neuer. But there are two matches, one at home (and) one away, so both teams have the chance to win."
Bayern chairman Karl-Heinz Rummenigge said the runaway Bundesliga leader "can be happy" with facing Arsenal, which has struggled this season.
"We can manage this. We're going as favorites there," Rummenigge said. "It's important that we try to get a good result in London, to score a goal and set down a marker."
Celtic manager Neil Lennon savored the prospect of another two classic encounters against Juventus after being paired with the Italian champions and Serie A leaders. Juve went through last season unbeaten in Serie A and currently sit seven points clear.
"They topped the group with Chelsea," Lennon said. "They beat Chelsea 3-0 and not many teams do that. I don't know how long they went unbeaten in the league. ...
"They have been very consistent in Serie A. They are easily the best team in Italy at the moment and they are formidable opponents. But over two games, who knows? And who knows where we will be in six or seven weeks time?"
Celtic will take on Juventus at Celtic Park on Feb. 12, with the return leg in Turin on March 6.
Hours before the draw at the headquarters of the Union of European Football Associations, Barcelona coach Tito Vilanova underwent surgery on his throat and faces weeks of chemotherapy and radiation treatments.
UEFA general secretary Gianni Infantino opened the ceremony with a message to "a friend of ours. Tito, we are all with you."
Information from Press Association and The Associated Press was used in this report.