Sampdoria on Monday sacked coach Ciro Ferrara and replaced him with ex-Fiorentina boss Delio Rossi.
Ferrara replaced Giuseppe Iachini on Samp's return to the top flight this summer, but the former Italy Under-21 coach has paid the price for a poor start to the Serie A season in which the Blucerchiati have won just five times.
Following Sunday's 3-1 defeat at Catania, Sampdoria issued a statement on their official website outlining the personnel changes.
The club also said it "has accepted the resignations of director of sport Pasquale Sensibile and technical co-ordinator Domenico Teti."
Carlo Osti was named to replace Sensibile as director of sport.
Ferrara's dismissal comes after bottom side Siena parted company with Serse Cosmi on Sunday night.
A former Juventus defender and manager, Ferrara guided newly-promoted Samp to three straight victories at the start of the current season, but came under intense scrutiny when the Ligurians lost seven straight games to slip quickly down the league standings.
The 45-year-old coach bought himself some more time with victory in the Genoa derby, followed by a 1-0 win over Bologna, but a run of three games without a win has persuaded Samp's management to make the change.
Rossi made his name in Italy during a four-year spell as Lazio manager, guiding the Biancocelesti to a third-place finish in 2007 and Coppa Italia glory in 2009.
An inconsistent stint in charge of Palermo was followed by a brief, dramatic tenure at Fiorentina.
The 52-year-old was sacked in May for attempting to punch Viola midfielder Adem Ljajic when he reacted sarcastically to being substituted.
Sampdoria sit 13th in the current standings and welcome Rossi's former club Lazio to the Stadio Luigi Ferraris on Saturday.