Michel Bastos came off the bench to give Lyon a 1-0 victory over St Etienne.
Lyon were left with only ten men when Mouhamadou Dabo was shown a red card for violent conduct, but substitute Bastos scored the only goal of the game to secure a victory that leaves the team five points clear of second-placed Paris Saint-Germain.
Marseille earlier blew the chance to make a brief return to top spot in Ligue 1 in spectacular fashion as Lorient ran out comfortable 3-0 winners at Stade Velodrome.
OM have endured a torrid time on home soil in recent weeks, with today's drubbing coming just a fortnight after they shipped four goals in a damaging defeat to title rivals Lyon.
The Stade Velodrome was enveloped in gloom once more today as goals from Jeremie Aliadiere, Benjamin Corgnet and Kevin Monnet-Paquet condemned the Mediterranean club to defeat, with the fans turning their ire against club president Vincent Labrune at the final whistle.
Bordeaux missed the chance to move into Ligue 1's top three as they were held to a 0-0 draw at lowly Reims.
The visitors had their chances, with Kossi Agassa making several decent saves and Yoan Gouffran volleying just wide late on.
But Reims actually had the better opportunities as Floyd Ayite hit the crossbar and Florent Ghisolfi forced a superb save from Cedric Carrasso.
Information from Press Association was used in this report.