Hulk has been ruled out of Zenit St Petersburg's Champions League game with Anderlecht through injury.
The Russian champions confirmed the news on their official website, saying the Brazil international, 26, is expected to miss up to two weeks with a thigh injury.
His absence is a blow to Zenit's chances of qualifying from Group C. They currently lie third, with three points, two points above Anderlecht, who they beat 1-0 last month in St Petersburg.
He has scored three goals in 11 appearances since signing for a Russian Premier League record of 60m this summer.
Hulk, who was injured in Friday's 2-1 league victory against Rostov, will also miss Brazil's friendly against Colombia in the United States on November 14.