The Netherlands assumed control of qualifying for the 2014 World Cup with a thumping 4-1 win of Romania in their top-of-the-table Group 4 clash in Bucharest.
Romania had not conceded a goal in its opening three wins, but its perfect record was in ruins within the opening 45 minutes as Jeremain Lens, Bruno Martins Indi and Rafael van der Vaart all found the target.
Robin van Persie then completed the rout four minutes from the end with Romania's consolation coming from a fine Ciprian Marica goal when they were 2-0 down.
Italy continue to set the pace in Group 2 with a 3-1 home win over Denmark.
Goals from Riccardo Montolivo (33) and Daniele De Rossi (37) put Italy in charge but a home win looked in question when Denmark pulled a goal back through William Kvist Jorgensen (45) and the Azzurri lost Pablo Osvaldo to a straight red card 18 seconds into the second half for violent conduct.
However, Italy was not made to pay for that dismissal as Mario Balotelli made it 3-1 in the 54th minute to complete the scoring.
Group 8 leader England saw its match with Poland postponed until Wednesday due to a waterlogged pitch in Warsaw.
In Group 1, Belgium and Croatia remain level on 10 points after claiming 2-0 home wins over Scotland and Wales, respectively.
The top two are now six points clear of third-placed Serbia, who went down to a 61st-minute Agim Ibraimi penalty at Macedonia.
Italy's lead in Group 2 now stands at four points after its two nearest challengers Bulgaria and Czech Republic drew 0-0 in Prague.
In Group 3, Austria claimed a deserved 4-0 win over Kazakhstan with goals from Marc Janko (two), David Alaba and Martin Harnik while Ireland bounced back from its mauling by Germany with a 4-1 win over Faroe Islands.
Three points behind the Netherlands in Group 4 is Hungary, which went behind to Mevlut Erdinc goal against Turkey but hit back to claim a 3-1 win thanks to efforts from Vladimir Koman, Adam Szalai and a Zoltan Gera penalty.
In the other group match, a 57th-minute Andres Oper header saw Estonia beat fellow strugglers Andorra 1-0.
Switzerland defeated Iceland 2-0 away from home with second-half goals from Tranquillo Barnetta and Mario Gavranovic and it remains three points clear of Norway at the top of Group 5.
Albania are in third place on six points after a Odise Roshi goal gave it a home victory over Slovenia.
Group 6 leaders Russia continued its 100 percent start with a 1-0 victory over Azerbaijan, although it needed an 84th-minute Roman Shirokov penalty to claim a fourth win out of four.
Portugal are now five points behind after being held to a shock 1-1 home draw by Northern Ireland.
It could have been worse for the star-studded Portuguese as it required a 79th-minute equalizer from Helder Postiga to even salvage a point after falling behind to a first-half Niall McGinn goal.
Bosnia-Herzegovina and Greece lead Group 7 with 10 points.
Bosnia-Herzegovina beat Lithuania 3-0 with goals from Vedad Ibisevic, Manchester City striker Edin Dzeko and Miralem Pjanic while Greece ended Slovakia's unbeaten start thanks to a Dimitris Salpingidis goal.
Also, Latvia beat 10-man Liechtenstein 2-0 at home with goals from Vladimir Kamess and Edgars Gauracs.
The other matches in England's group saw Montenegro join Roy Hodgson's men on seven points after beating Ukraine with Dejan Damjanovic netting the only goal, while second-half goals from Serghei Dadu and Alexandru Epureanu gave Moldova a 2-0 win at San Marino.
In the Spain-France group, Belarus beat Georgia 2-0 with Renan Bressan and Stanislav Dragun on the scoresheet.