Liverpool triumphed in their opening Europa League match in Group A as they beat Young Boys 5-3 in a topsy-turvy match at Wankdorf Stadium.
The Italian giants came to White Hart Lane on the back of a five-match winning streak, but they were outplayed for large parts of their Group J clash, which Villas-Boas will feel his side should have won.
Elsewhere in Group J, Maribor claimed their maiden Europa League group stage victory after downing Panathinaikos 3-0 in impressive fashion. Shola Ameobi came agonisingly close to firing Newcastle to an opening Europa League victory in Group D as the woodwork and Maritimo goalkeeper Romain Salin combined to thwart him in a game that ended goalless. The 30-year-old, captaining a much-changed side at the Estadio dos Barreiros, hit both the post and the crossbar and saw Salin block another effort on a frustrating evening for the Magpies in Madeira. Also in Group D, Bordeaux began their campaign with a dominant 4-0 win over Club Brugge which lifted them to the top of the standings. Ludovic Sane and Yoan Gouffran gave Les Girondins a first-half lead before substitute Bjorn Engels added an own goal early in the second half. Jussie then rounded off the scoring in the one-sided contest at Stade Chaban Delmas. Yuto Nagatomo's stoppage-time goal salvaged a point for Inter Milan in their Europa League Group H 2-2 draw at home against Rubin Kazan.
The Russian side went ahead in the 17th minute when Alexander Ryazantsev tucked in the rebound after Inter goalkeeper Samir Handanovic kept out Bebras Natcho's penalty, before the Italian giants pulled level thanks to Marko Livaja's 39th-minute header.
Jose Salomon Rondon then struck what appeared to be a shock winner for Rubin with six minutes to go, only for Nagatomo to equalise in the dying moments, in a group which also saw a goalless opening game between
Partizan and Neftchi in Belgrade.
In Group B, holders Atletico Madrid got the defence of their title up and
running in fine style with a 3-0 win over Hapoel Tel Aviv in Israel.
Adrian Rochet's goal gave the Israeli champions the lead against last season's beaten finalists at San Mames.
Although Markel Susaeta levelled the scores before half-time and Athletic looked the more likely winners after the break, Gili Landau's men held on for a point on a memorable night.
Also in Group I, Lyon made hard work of a straightforward 2-1 victory over Sparta Prague, with defender Mouhamadou Dabo sent to hospital after suffering a serious head injury.
FC Copenhagen demonstrated their European pedigree with an opening 2-1 victory in
Europa League Group E against Ole
Gunnar Solskjaer's Molde.
Georg Niedermeier's late header saw Stuttgart deny Steaua Bucharest a first win
over German opposition in 55 years in their Europa League Group E opener as they played out an entertaining 2-2 stalemate.
In Group F, Dnipro got their Europa League campaign off to the perfect start as two
second-half goals saw them get the better of PSV with a 2-0 win in Ukraine.
Napoli, currently second in Serie A, claimed an emphatic 4-0 win over AIK in
Group F with a hat-trick from Eduardo Vargas and a fourth from Blerim Dzemaili
in injury time.