Wilson Palacios will be one of the biggest names to lose out at Stoke City - following the arrival of Michael Owen.
Stoke City chairman Peter Coates has instructed manager Tony Pulis to trim the squad and reduce the mounting wage bill by clearing out fringe players at the Britannia Stadium.
Coates wants the club to operate on a tighter budget, after heavy investment over the last three seasons, including signing another seven players this summer.
Stoke chief executive Tony Scholes confirmed that Coates is now looking for some significant reductions in playing staff during the emergency loan window.
"The fact we have made seven signings speaks for itself. The backing that the Coates family has again given the club is incredible," Scholes said. "Now we have to balance things and move some players out as well. It's fair to say we have ended up with more in the squad than is appropriate."
Honduras international Palacios - who only moved to the club from Spurs for £7m just over a year ago - will be allowed to move on loan, along with a host of other unwanted players.
Danny Higginbotham, Michael Tonge, Diego Arismendi and Mamady Sidibe have all been left out of the club's 25-man Premier League squad.
Stoke plan to circulate their names to Championship clubs in attempt to lower the wage bill in the short term.
Palacios has been included in the Premier League squad, but he is also likely to be offloaded.
He has struggled to settle since the move from White Hart Lane and has been training with the club's development squad since returning for pre-season.