African champions Zambia again got the better of Ghana with a 1-0 triumph in their World Cup qualifier in Ndola.
The Black Stars began their Group D campaign by thrashing Lesotho 7-0 on June 1, but failed to make it two victories from two as Christopher Katongo's 18th-minute goal ensured Zambia ran out 1-0 winners - just as they had done when the teams met in the African Nations Cup semi-final earlier this year.
Elsewhere, South Africa failed to win for an eighth successive match. They were held to a 1-1 draw by Botswana in Gaborone.
Bafana Bafana sacked Pitso Mosimane earlier this week after managing only a 1-1 draw in their opening Group A game last weekend, with interim coach Steve Komphela expressing his optimism before kick-off today that three points would get the team back on track.
All was going well when Morgan Gould gave the visitors a 17th-minute lead, but Ofentse Nato equalised six minutes before the break to secure a point for Botswana - their first of the pool campaign after they were beaten 2-0 by Central African Republic last time out.
Newcastle striker Papiss Cisse opened the scoring for Senegal against Uganda, but Godfrey Walusimbi kept his cool to convert a penalty four minutes from time which ensured the Group J match finished 1-1.
There was late drama in Group F, with Ruben Gabriel breaking the deadlock for Nigeria in the 89th minute only for substitute John Banda to nick a 1-1 draw for Malawi two minutes into stoppage time.
Issam Jemaa notched the winner three minutes into the second half as Tunisia made it two wins from two in Group B with a 2-1 success over Cape Verde Islands in Praia.
Saber Khelifa earlier put the Tunisians ahead in the 13th minute only to see Odair Fortes restore parity 11 minutes later.
In the same pool, Edjogo-Owono Juvenal started and finished the scoring for Equatorial Guinea to earn the hosts a 2-2 draw against Sierra Leone in Malabo.
All the goals came in the first half, with Samuel Barley and Umaru Bangura on target for the visitors in between Juvenal's brace.
Elsewhere, Henrico Botes grabbed the only goal of the game in Windhoek as Namibia edged past Kenya 1-0 to secure their first three points of the Group F campaign.