Ottmar Hitzfeld's Switzerland beat his home country in an eight-goal thriller in Basel, giving Germany coach Joachim Low plenty of food for thought with just days to go before he has to hand in his 23-man squad for Euro 2012.
It was Switzerland's first win over Germany in 56 years and one they will remember for a long time to come as a hat-trick from Eren Derdiyok and further goals from Stephan Lichtsteiner and Admir Mehmedi earned them a resounding 5-3 victory.
A stoppage-time header from Bulgaria's Iliyan Mitsanski handed the Netherlands a surprise 2-1 defeat in Amsterdam ahead of the finals.
Robin van Persie, who was partnered by Klaas Jan Huntelaar up front in a near full-strength Oranje team, opened the scoring after 45 minutes. But Ivelin Popov equalised with a 50th-minute penalty, after Rafael van der Vaart handled in the area, before Mitsanski won it.
It is a disappointing result for Bert van Marwijk's men, who will travel to Poland and Ukraine next month as one of the tournament favourites following their runners-up finish at the 2010 World Cup.
An early goal from Ashley Young ensured new England manager Roy Hodgson began his tenure on a positive note, with a 1-0 victory against Norway in Oslo.
However, the victory may have come at cost with Gareth Barry picking up an injury that could rule him out of the European Championships. The Manchester City midfielder limped off with a hamstring injury just 25 minutes after coming on.
Young earned England their first win over the Norwegians since 1980 with a clinical finish after only nine minutes.
Second-half goals from Adrian Lopez and Santi Cazorla were enough to hand a makeshift Spain side a 2-0 victory over Serbia in Saint Gallen.
Xabi Alonso had come closest to breaking the deadlock in a poor first-half with an audacious effort from well inside his own half that drifted just over the bar.
However, the introduction of Adrian on his international debut after the break provided the spark that the world champions needed as he first headed home Jesus Navas' teasing cross and was then brought down by Branislav Ivanovic to allow Cazorla to seal the victory from the penalty spot with 15 minutes remaining.
Brazil striker Hulk scored twice and had a hand in Niki Zimling's own goal as EURO 2012 qualifiers Denmark produced an error-strewn display in a 3-1 defeat in Hamburg.
The Porto forward was in the squad as a replacement for Neymar, who had Copa Libertadores commitments, took just seven minutes to open the scoring with a powerful long-range shot which dipped beneath the dive of goalkeeper Thomas Sorensen.
Brazil were two ahead four minutes later when Oscar's cross into the box was turned into his own net by the unfortunate Zimling and made it 3-0 before half-time when Hulk finished from a laying off from Oscar.
Denmark, who saw Sorensen and midfielder Lasse Schone go off injured, netted a consolation goal through Nicklas Bendtner.
Shane Long ensured the Republic of Ireland will head off on their Euro 2012 adventure on the back of a victory with the only goal in a 1-0 win against Bosnia-Herzegovina. The West Brom striker's 78th-minute header was enough to claim victory in the Republic's final game on home soil before the finals.
Giovanni Trapattoni's men might have won more comfortably in front of a crowd of 37,100 with the post, the bar and the heroics of keeper Asmir Begovic denying them.
The win extended Ireland's unbeaten run to 13 games a day before they leave for their pre-tournament training camp in Montecatini, Italy.
Trapattoni had chosen the Bosnians because he knew they would be technically adept and tactically astute, and would provide his side with exactly the sort of challenge they will face next month with Croatia, Spain and Italy standing between them and their dream of reaching the quarter-finals.
Euro 2012 co-hosts Poland grabbed a 1-0 win over Slovakia, Damien Perquis deciding the contest on 30 minutes.