Lionel Messi wrote himself into the record books once more as his four goals in Barcelona's 4-0 win over Espanyol saw him reach 50 goals in La Liga and 72 in all competitions this season.
In Pep Guardiola's final home game in charge before he stands down to make way for his assistant Tito Vilanova, he received a parting gift from arguably the most influential player over his four-year reign.
Messi was again magnificent as he netted four times to move onto 251 in 327 Barcelona appearances.
The Argentinian opened the scoring with a free-kick and completed his hat-trick with a trademark burst and finish. Goals two and four were from the penalty spot even though Espanyol could feel aggrieved by both spot-kick awards.
Real Madrid shook off their title-winning hangover in the nick of time to serve Granada a relegation warning with a 2-1 win. Having wrapped up their 32nd championship in midweek, the capital club appeared to still be in celebration mode when Franco Jara put Granada ahead with five minutes gone.
That was taking them clear of relegation for the season, only for their situation to be turned on its head in a dramatic final 10 minutes. First, Cristiano Ronaldo won and converted an equalising penalty, before David Cortes put Karim Benzema`s injury-time cross into his own goal.
Then, at the final whistle, Granada's players surrounded police-protected referee Clos Gomez, with Cortes and Borja Perez shown red cards, while the official also seemed to be hit by a bottle thrown by one of the players.
Jonas' scored deep into injury time to ensure Valencia will finish in third for the third successive season, deepening Villarreal's relegation fears in the process.
A wonderful goalkeeping performance from Diego Lopez looked to have snatched a point for the visitors as he denied twice denied Pablo Piatti and Aritz Aduriz, before Pablo Hernandez also hit the post late on. However, two minutes into stoppage time, Jonas controlled Aduriz's flick-on and smashed the ball past Lopez to win the game in dramatic fashion.
Real Zaragoza got the win they desperately needed to keep their survival hopes alive but they had to come from behind to see off Racing Santander 2-1.
Christian Fernandez headed in an early goal for the visitors which stunned the home crowd. But Helder Postiga headed them level only two minutes later before a frustrating period where they piled on pressure for more than hour without reward.
Just when they feared time was beginning to running out, Angel Lafita finished from close range to snatch the points they needed to move level with 17th placed Rayo Vallecano.
A goal in each half by Gaston Sangoy lifted Sporting Gijon to a crucial 2-1 victory over Real Betis that keeps their survival hopes alive heading into the final week of the season.
The win lifted second-bottom Sporting onto 37 points, three behind Real Zaragoza and Rayo Vallecano - the latter occupying the final position of safety - ahead of their match against Malaga next week.
Sevilla beat Rayo Vallecano 5-2 to increase their visitor's relegation worries. Knowing a win could all but end their fears of dropping out of the Primera Division, Rayo were always chasing the game despite Diego Costa's brace.
Baba Diawara opened the scoring for Sevilla and, although Costa levelled from the spot, Juan Cala, Diawara again and Jose Antonio Reyes took the home side clear. Costa scored his second but Freddie Kanoute sealed things late on to send Rayo into a do-or-die clash with Granada next weekend.
Atletico Madrid scored twice in the final 25 minutes to keep their hopes of Champions League qualification alive with a 2-1 win over Malaga. The visitors had the better of the opening period and deservedly took the lead eight minutes before the break when Eliseu's wonder strike from fully 30 yards rocketed into the top corner.
However, Atleti improved greatly after the break and were back on level terms midway through the half thanks to another brilliant strike, this time from Koke. And Adrian Lopez completed the comeback as he raced onto along ball over the top to slot past Carlos Kameni and bring Diego Simeone's men to within two points of Malaga in fourth with just one game to play.
Osasuna kept up their hopes of European football next season with a narrow 1-0 win over Real Sociedad. Ibra Balde got the goal after 14 minutes and it proved enough despite sustained Osasuna pressure that never translated into a second.
Mallorca leapfrogged Levante to move into the top six as Tomas Pina's second-half strike was enough to give them a narrow 1-0 win at the Iberostar. Joaquin Caparros' side's dominance was more controlled in the second period and they deservedly went in front as Chori Castro's corner picked out Pina on the edge of the edge of the area and he steered the ball past Gustavo Munua.
The only game of the day that finished 0-0 was between Athletic Bilbao and Getafe; a result which does little for either side as they sit 10th and 11th.