Paris St Germain turned up the heat on Ligue 1 leaders Montpellier with a 2-0 victory at home to St Etienne.
Nene's controversial first-half penalty and Javier Pastore's late clincher moved the capital club three points behind Montpellier, who drew yesterday, with three games to go.
The hosts were dominant from start to finish and twice hit the post as their opponents did not get a look in.
Tulio de Melo's early goal kept Lille's slim title hopes alive with a 1-0 victory at struggling Nice.
De Melo headed home in the sixth minute to move Lille five points behind leaders Montpellier with three games to go. Lille travel to the leaders in their penultimate game. Defeat, though, left Nice three points above the bottom three.
Lisandro Lopez followed up his cup-winning goal at the weekend with a brace as Champions League-chasing Lyon downed Valenciennes 4-1 at Stade Gerland.
Lisandro struck in the 34th and 71st minutes, with Cris (68) and Jimmy Briand (87) also on the scoresheet for the hosts, who climb up to fourth above Rennes.
Valenciennes, who had equalised through Renaud Cohade's first-half equaliser, are still not safe from relegation, although they are six points clear of the relegation zone with three games remaining.
Loic Remy's first-half strike saw Marseille record a first win, 1-0 over Nancy, in 14 games at Stade Velodrome.
Remy, a reported target for Tottenham, slotted the only goal of the game on the half-hour mark from Mathieu Valbuena's superb pass as OM picked up three points for the first time since January 29.
Rennes' Europa League aspirations suffered a setback with 2-0 defeat to mid-table Bordeaux.
Ludovic Obraniak and Landry N'Guemo scored the goals for the home side to mark their third successive victory. Defeat for Rennes ended a four-match winning run and saw them slip out of the top four and the European places.
Caen moved four points clear of the relegation zone as a solitary goal by Thomas Heurtaux guided them to a 1-0 win over Lorient.
Heurtaux struck midway though the second half with a spectacular shot from distance as they drew level on points with their visitors, who enjoy a slightly superior goal difference.
Ajaccio boosted their hopes of survival and left Sochaux deep in trouble after a dramatic 2-1 encounter in Corsica.
Sloan Privat gave the visitors the lead in the 58th minute but they were then reduced to nine men as David Sauget and Yassin Mikari both saw red and gave away penalties. Johan Cavalli saw his effort saved but Christian Kinkela made no mistake from the second spot-kick and Richard Socrier netted the winner four minutes from time.
Brest nudged out of the relegation zone with three games to play after a goalless draw with Toulouse which severely dented the visitors' hopes of reaching the Europa League.
One win and seven losses from their last eight games had seen Corentin Martins' hosts collapse into the bottom three but they were denied a vital win when Bruno Grougi missed a second-half penalty.