Club America squandered a two-goal lead against Cruz Azul and missed out on the chance to go second in Mexico's Clausura as a result.
Christian Benitez netted twice inside the first 13 minutes to put the home side in control of the contest.
But Jair Pereira pulled a goal back midway through the first half and earned his team a point with an equaliser 17 minutes from time - before marring his performance with a late dismissal.
The two dropped points mean Santos Laguna maintain a four-point advantage at the top of the table.
Tijuana and Unam Pumas drew 1-1, with Duvier Riascos putting Tijuana ahead, only for Javier Cortes to take advantage of the 87th minute sending-off of the home side's Joshua Abrego with an equaliser two minutes later.
Toluca defeated struggling San Luis 2-1, with Ivan Alonso netting both goals for the hosts, either side of Facundo Pereyra's 58th-minute equaliser.