Brazilian side Santos came from behind to defeat Peruvians Juan Aurich 3-1 in Group One of the Copa Libertadores.
Luis Tejada broke the deadlock with a volley after 14 minutes, but Santos equalised just before the break through defender Fucile.
Santos extended the advantage with Ganso's outstanding free-kick.
Things got worse for the Peruvians as Luis Guadalupe earned a second yellow card, before Borges made the points safe for Santos.
Brazilian giants Flamengo surrendered a three-goal lead to draw 3-3 with Olimpia of Paraguay in Group Two.
Vagner Love set up Argentinian Dario Bottinelli for the first, before man-of-the-match Ronaldinho extended the advantage from the spot in the second half and midfielder Luiz Antonio made it three.
Pablo Zeballos pulled one back for the visitors and Luis Caballero made it 3-2 with four minutes to go, then Vladimir Marin levelled with a superb volley.
Despite the late goals, Fla remained unbeaten with five points from three games to sit top of the group.