Sunderland will be without skipper Lee Cattermole for four games and star forward Stephane Sessegnon for three after the duo were sent off in a feisty Tyne-Wear derby against Newcastle United on Sunday.
Cattermole was booked after just 45 seconds of the 1-1 draw at St James' Park for a tackle on Cheick Tiote and was sent off by referee Mike Dean for foul and abusive language after the final whistle.
The midfielder has now been suspended for four games - two for accumulating ten yellow cards this season and a further two for his eventual red card.
Forward Sessegnon was sent off for elbowing Newcastle's Tiote in the throat early in the second-half and will serve a three-match suspension.
A spokesman said: "Stephane Sessegnon and Lee Cattermole have been handed three- and four-game bans respectively."
Both men will miss the FA Cup quarter-final trip to Everton and the league games against Liverpool and Blackburn either side of it, while Cattermole will also sit out the home clash with QPR on March 24.
Referee Mike Dean endured a trying afternoon on Tyneside, issuing eight yellow cards and two red and also sending Newcastle's goalkeeping coach Andy Woodman to the stands at half-time.
He also awarded two penalties, the first of which was converted by Black Cats striker Nicklas Bendtner, but was cancelled out in injury time by Magpies substitute Shola Ameobi after Simon Mignolet had saved Demba Ba's spot-kick.