Ferguson revealed Rooney will not be available for the match due to a throat infection while also confirming midfielder Cleverley will be absent.
"They'll be out,'' he told Sky Sports News after his side's Premier League win at Norwich on Sunday.
"Wayne has still not recovered from his throat infection, so hopefully we'll get him ready for next Sunday, when we have a big game at White Hart Lane.''
Both players had been rated doubtful for this weekend's match, Rooney suffering from illness and Cleverley reportedly struggling with a recurrence of his recent ankle injury.
The news is a blow for caretaker England boss Stuart Pearce, who on Saturday lost Rooney's probable strike partner Darren Bent when he injured his ankle playing for Aston Villa at Wigan.