Joe Cole scored a hat-trick as defending champions Lille hammered lowly Chantilly 6-0 in the ninth round of the Coupe de France.
Marseille also claimed a comprehensive win with a 5-0 success at Red Star, but Ligue 1 sides Sochaux, Caen, Brest and Lorient were knocked out by lower-league opposition.
England midfielder Cole opened the scoring for Lille in the 23rd minute and Eden Hazard. added a second from the spot.
Ireneusz Jelen made it 3-0 shortly after the break before Cole struck twice more to complete his treble and Jelen added a sixth.
Jordan Ayew scored twice for OM, opening the scoring in the 43rd minute and sealing the win in the 90th.
Mathieu Valbuena, Andre Ayew and Benoit Cheyrou also netted after the break as Marseille cut loose as the match wore on.
Ligue 2 side Bastia beat top-flight strugglers Sochaux 4-1 with a brace from David Suarez. Jeremy Choplin put them ahead in the second minute and Suarez made it two.
Yassin Mikari pulled one back early in the second half before another from Suarez and a Wahbi Khazri effort sealed the victory.
Troyes, also of Ligue 2, scored twice in extra-time to win 4-2 at Caen. Goals from Thiago Xavier and Raphael Caceres put the visitors two up, but Caen came back after the break with Thomas Heurtaux and Faycal Fajr on target.
However, Troyes ensured their progression with two goals in extra-time courtesy of Marcos (100) and Sebastien Grax (113).
Third division Chamois Niortais beat Brest 2-0 thanks to goals from Mouhamadou Diaw and Jimmy Roye, while Ligue 2 Le Havre edged out Lorient 4-3. Mathieu Coutadeur and Jacques Romao scored two quickfire goals to put Lorient 2-1 in front after James Fanchone's early opener.
Benjamin Genton and Fanchone again scored either side of half-time to put Le Havre back in front again only for Arnold Mvuemba to make it 3-3. But substitute Yohan Riviere struck 10 minutes of time to earn Le Havre victory.
Elsewhere, Bordeaux beat St Etienne 4-2 on penalties after the match ended 1-1 and Rennes saw off Nancy 3-0.
Nice won 2-0 at AS Marck, Auxerre beat Chambly Thelle 1-0, Ajaccio were 3-0 winners over Frejus Saint-Raphael and Dijon swept aside Versailles 5-1.
Also through to the next round are Limoges, Sable-sur-Sarthe, US Orleans, Tours and Valence.