Atletico Madrid cruise past Real Sociedad, Las Palmas beat Getafe
Diego Simeone's side took an eighth-minute lead through Diego Reyes' own goal, then Saul Niguez put them further at ease by volleying home a minute into the second half.
Former Sociedad forward Antoine Griezmann added the third from the penalty spot, converting for the first time from 12 yards in the Primera Division.
The Rojiblancos consolidate second place thanks to their second straight league win, moving five points behind Barcelona who play on Thursday, while La Real suffered a first defeat in six matches.
Despite playing a fourth game in just 10 days, Simeone made just one change from the team that won 1-0 at neighbours Real Madrid on Saturday, bringing in Luciano Vietto for Fernando Torres.
His opposite number Eusebio Sacristan made six changes from the team that drew 1-1 with Malaga.
Las Palmas boosted their bid to avoid relegation by thrashing fellow strugglers Getafe 4-0.
An early strike from Willian Jose and a penalty from top-scorer Jonathan Viera put them in charge at half-time, and a double from midfielder Tana after the break set up the hosts' biggest victory of the season.
While Getafe were unlucky to lose 1-0 to Celta last weekend, they were well beaten at the Estadio Gran Canaria and had debutant Alvaro Pereira sent off midway through the second half.