Real Betis and Real Madrid played to a 1-1 draw in Seville, with Karim Benzema providing the equaliser for Zinedine Zidane's team.
Betis opened the scoring early on when Fabian found Alvaro Cejudo and the Spaniard blasted a shot past Keylor Navas in the seventh minute.
Real Madrid had the better of the chances and possession throughout the first half, but Betis still took a 1-0 lead to the dressing room at half-time.
Benzema finally got Madrid on the scoresheet in the 71st minute, as he slotted home from six yards out, with the assist going to James Rodriguez.
James almost found the winner in the 78th minute, but Betis goalkeeper Antonio Adan parried his left-footed blast away.
Seconds later, Benzema was denied from close range after a Toni Kroos centering pass was just behind the Frenchman, who couldn't hold up and get a good shot on goal.
Ruben Castro nearly scored an injury-time winner, but his left-footed blast from outside the box tailed wide of the left post.
The draw leaves Real Madrid in third place in the La Liga table, four points behind leaders Barcelona.
Atletico Madrid missed the chance to go top of La Liga as 10-man Sevilla battled to a 0-0 draw at the Vicente Calderon.
Diego Simeone's side had the chance to retake first place from Barcelona before kickoff, but Atletico were left frustrated as they could not find a way past their determined visitors.
Antoine Griezmann hit the post and Sevilla then saw Vitolo dismissed just after the hour mark for a second bookable offence.
However, Simeone's title chasers could only claim a draw to send them level on points with Barca having played a game more than Luis Enrique's men.
Alvaro Negredo headed home in the third minute of stoppage time to give Valencia a 1-1 draw at Deportivo and earn a point Gary Neville's side barely deserved.
Lucas Perez pounced on a defensive lapse to put the hosts in charge in the 27th minute and had a goal wrongly ruled out for offside in the second half.
Although Valencia made an encouraging start, Victor Sanchez's side were the better team for the majority of the game but were unable to add to their lead, and Negredo made them pay late on by nodding in Dani Parejo's cross.
The draw takes Valencia ahead of Malaga and up to 11th in the Primera Division, although they are still looking for a first league win under the English coach, while Depor drop down to ninth place.
Athletic Bilbao came from behind to secure a 5-2 win over Eibar.
Eibar took the lead in just the fourth minute when on-loan striker Borja Baston finished off a counter attack with a neat finish, but the visitors were in front for less than 10 minutes when Athletic equalised through Aritz Aduriz.
Bilbao were ahead on 27 minutes courtesy of a header from forward Sabin before Aymeric Laporte made it 3-1 just five minutes before the break.
Eibar clawed one back on 50 minutes through Baston from the penalty spot after a foul by Laporte, but the hosts regained their two-goal advantage just two minutes later when Aduriz tapped home a Mikel Balenziaga cross for his second.
The result was confirmed when Argentine defender Mauro Dos Santos turned the ball into his own net on 80 minutes.