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Timo Werner's double led the way in a first-half scoring frenzy as Leipzig picked up an important victory in Group G.
Cristiano Ronaldo didn't show any signs of his La Liga struggles, netting two goals and providing an assist in Real's win over APOEL.
Sevilla completed an improbably comeback after going down 3-0 in the first half to Liverpool.
Manchester City ensure a first place finish in Group F after beating Feyenoord 1-0.
Lorenzo Insigne's wonder goal inspired Napoli's second-half surge to seal three vital points in Group F.
Cristiano Ronaldo scored twice and added an assist as Real Madrid secured their place in the last 16 with a resounding win.