The draw is due to take place from around midday GMT, 7 a.m. ET on Friday, Feb. 24.
Vincent Aboubakar sank Hapoel Be'er's comeback hopes with a stunning strike as Besiktas advance to the round of 16.
Villarreal's spirited effort was not enough to overcome a 4 goal aggregate deficit, as Roma advance to the round of 16.
A dramatic late header from Kiese Thelin sends Anderlecht to the round of 16 on away goals.
Athletic Bilbao crashed out of the Europa League in the round of 32 on Thursday with a 2-0 defeat at APOEL, falling 4-3 on aggregate.
Ajax just needed one goal over the tie to beat Legia Warsaw and move on to the round of 16.