Despite two red cards, San Jose scored a late goal to earn a stunning home win over Toronto FC.
Fifteen-year-old Alphonso Davies made his MLS debut as Vancouver squandered a 2-1 halftime lead at home against Orlando City.
Neither Real Salt Lake nor New England could break the deadlock as their match at Rio Tinto Stadium ended scoreless.
Major League Soccer: Simon Dawkins: (70'), San Jose Earthquakes 2-1 Toronto FC
Rayo OKC scored three second-half goals to beat the New York Cosmos and earn a six-game unbeaten streak.
Colorado's unbeaten streak reached 14 matches as Marlon Hairston's sensational strike propelled the Rapids to three points against rival Sporting KC.