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Madrid need the defeat of APOEL to mean more than 3 points and progression in the Champions League. They need it to catalyse a reaction in La Liga.
Denis Suarez insists there is no panic among the Barcelona players as the wait goes on for Lionel Messi to sign his new contract with the club.
Ramos suffered the broken nose in the recent draw at Atletico Madrid, while Navas has been sidelined by a muscle injury.
Valencia coach Marcelino will have to watch Sunday's game against La Liga leaders Barcelona from the Mestalla stands.
Radja Nainggolan has reiterated how happy he is to be a Roma player after Atletico Madrid coach Diego Simeone revealed his interested in him.
If results go their way this weekend, Real's rally for a La Liga title is on. If they don't, the headlines won't make for good reading in Madrid.