In a battle of teams coming off of US Open Cup Quarterfinal wins, Kei Kamara and the New England Revolution look to get back into the Eastern Conference playoff conversation against the Chicago Fire.
The Montreal Impact look to bounce back from last weekend's loss as the Philadelphia Union come to challenge them at Stade Saputo.
Orlando City overcame a 2-0 deficit to earn a point on the road in their final match before Jason Kreis takes charge.
Sebastian Giovinco scored a hat trick that included two goals from free kicks in a 4-1 Toronto FC win over DC United.
Watch all three of Didier Drogba's goals for the Montreal Impact against the Philadelphia Union.
Major League Soccer: Sebastian Giovinco (39'), Toronto FC 3-1 DC United