The draw is due to take place around 10 p.m. GMT, 5 p.m. ET on Wednesday, Nov. 30.
Ben Woodburn has become the youngest player to score for Liverpool, while Gareth Bale has successfully undergone ankle surgery.
Manager Jurgen Klopp made eight changes for EFL quarterfinal tie, with goals from Divock Origi and Ben Woodburn securing victory.
With injuries to Coutinho, Adam Lallana and Daniel Sturridge, Divock Origi is suddenly first in the striking pecking order after some good form.
Captain Lucas Leiva admitted that his mind was on the Chapecoense air disaster during Liverpool's 2-0 EFL Cup win over Leeds United.
Southampton manager Claude Puel believes his players are talented enough to win a trophy as they prepare to face Arsenal in the EFL Cup quarterfinal.