Manchester United striker Marcus Rashford is not in consideration for Euro 2016, but could be elevated to the national under-21 set-up soon.
On-loan Hull striker Chuba Akpom opened the scoring for England just after the break and Southgate's side had numerous opportunities to seal the win.
England U-21s boss Gareth Southgate has handed debut call ups to three players ahead of his team's European Championship qualifier in Switzerland
Gerard Deulofeu said he is enjoying captaining Spain's next generation after scoring a hat trick for the under-21 side in their 5-0 win over Georgia.
A hat-trick by Gerard Deulofeu led the way for Spain as they easily defeated Georgia 5-0 in U-21 European qualifier action.
England under-21s have drawn 0-0 away to Bosnia and Herzegovina to maintain their unbeaten start to qualification for the 2017 European Championship.