Man United are set up neatly for their Europa League round-of-32 return leg after Zlatan Ibrahimovic led them to a 3-0 first-leg win vs. St. Etienne.
Klaas-Jan Huntelaar scored his 50th goal in UEFA competition to seal Schalke's 3-0 victory over PAOK Salonika.
Besiktas hit Hapoel Be'er Sheva for three away goals, capped by a finish from Canadian international Atiba Hutchinson.
Edin Dzeko notched a second-half hat trick to help seal Roma's first leg win against Villarreal.
Frank Acheampong scored two stellar goals as Anderlecht beat Zenit 2-0 in their first-leg clash in the Europa League.
Behind Zlatan Ibrahimovic's hat trick, Man United took a commanding lead in their UEL round of 32 tie against St Etienne.