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Isco was released by Spain after taking a knock in Saturday's 5-0 friendly win over Costa Rica.
La Liga president Javier Tebas acknowledges that Neymar's summer departure from Barcelona to Paris Saint-Germain has had an effect on La Liga.
Duo, who had been on international duty, completed the team's third training session of the week.
Cristiano Ronaldo wants to leave Real Madrid next summer, according to fresh reports in Spain.
Atletico Madrid president Enrique Cerezo says he has no reason to believe Antoine Griezmann wants to leave amid links to PSG and Manchester United.
Ronaldinho says Philippe Coutinho would "perfectly suit" his former club Barcelona and hopes the Liverpool midfielder can finally secure a move.