Liverpool's familiar inability to see off the league's lesser lights reared its head again as Philippe Coutinho struggled in the 1-1 draw with Burley.
Jamaal Lascelles was Newcastle's hero for the second time in a week as Rafael Benitez celebrated his return to the dugout with a third successive win.
Jamie Vardy's penalty rescues a point for Leicester, who were lucky to see a Huddersfield winner ruled out.
Aguero spearheaded a rampant triumph, also laying on a goal for Gabriel Jesus as he inched ever closer to City's all-time goalscoring record.
Three goals in 10 first-half minutes set Man City on their way to an easy win at Vicarage Road. The result sees them go top of the Premier League.
Three-goal Sergio Aguero was the star for Manchester City as they embarrassed Watford.