Tottenham Hotspur face Crystal Palace as Watford play host to Chelsea, and Liverpool travel to Burnley hoping to build on their win at Arsenal.
Ryan Giggs believes Paul Pogba showed he is a player who "can do everything" after a superb debut against Southampton.
Belgium international Christian Benteke has completed his move to Crystal Palace from Liverpool.
Slaven Bilic will be asking for a big effort from his West Ham players when they host Bournemouth on Sunday.
Defiant Sunderland boss David Moyes is refusing to admit defeat in his battle to keep hold of Lamine Kone.
Southampton were toothless in attack and only spared a more lopsided loss versus Man United thanks to the play of Virgil van Dijk.