Seamus Coleman was stretched off after a challenge by Neil Taylor as Ireland and Wales shared the points in Dublin.
Gianluigi Buffon kept a clean sheet in his 1,000th professional appearance for club and country as Italy beat Albania 2-0 in a World Cup qualifier.
Four players got in on the scoring for Spain as they routed a helpless Israel side in World Cup Qualifying.
Republic of Ireland defender Seamus Coleman left his side's goalless draw against Wales with what appeared to be a serious leg injury.
Two first-half goals were enough for Iceland to hold off Kosovo in Group I of UEFA World Cup Qualifying.
Spain maintained their slim lead in UEFA World Cup qualifying Group G following a 4-1 win at home over Israel.