Missing Martin Olsson at the back and with Fernando Llorente likely limited, Paul Clement and Swans travel to Bournemouth in need of a new game plan.
Bournemouth should claim victory over Swansea, but nothing's ever as easy as it seems. Josh King will be key to the Cherries overcoming inconsistency.
Liverpool have reason to be confident but must be careful not to rattle the cage of a Manchester City side coming off a Champions exit.
Tottenham's Mauricio Pochettino faces his former club, Southampton, this weekend. Whatever the result, he should consider signing several Saints.
Pep Guardiola says he will not change his playing style for Liverpool after the defeat to Monaco in the Champions League.
Get all the latest team news and information for the next round of Premier League action.