Barcelona star Lionel Messi will be out for three weeks, while Jose Mourinho's Manchester United are to take on City in the EFL Cup fourth round.
Liverpool midfielder Emre Can admits he will have to prove himself all over again in order to regain his place in the team.
Manchester United boss Jose Mourinho has said football is "full of Einsteins" in a retort at criticism he has received following a poor run of form.
Swansea boss Francesco Guidolin reckons his side did enough to earn a draw in their EFL Cup 2-1 loss to Manchester City on Wednesday.
Alan Pardew questioned the penalty decision in Crystal Palace's 2-0 EFL Cup loss to Southampton on Wednesday.
Sunderland manager David Moyes hopes his side can build momentum following their 2-1 win at QPR in the third round of the EFL Cup.