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Tottenham flopped once again in a big game and were punished by Arsenal as Mauricio Pochettino's dour record in high profile matches continued.
Arsenal beat Tottenham 2-0 in the north London derby thanks to goals from Shkodran Mustafi and Alexis Sanchez.
Sadio Mane will start for Liverpool on Saturday afternoon against Southampton, while Joel Matip misses the game through injury.
Arsenal striker Alexandre Lacazette was named in the starting XI against Tottenham, who selected Harry Kane, Dele Alli and Hugo Lloris for the derby.
Manchester City manager Pep Guardiola played down claims his side are playing perfectly, stating everyone in the club still has room to improve.