Klaas-Jan Huntelaar scored his 50th goal in UEFA competition to seal Schalke's 3-0 victory over PAOK Salonika.
Edin Dzeko notched a second-half hat trick to help seal Roma's first leg win against Villarreal.
Frank Acheampong scored two stellar goals as Anderlecht beat Zenit 2-0 in their first-leg clash in the Europa League.
Behind Zlatan Ibrahimovic's hat trick, Man United took a commanding lead in their UEL round of 32 tie against St Etienne.
A Zlatan Ibrahimovic hat trick gave Manchester United a 3-0 win against St Etienne in a Europa League round of 32 first leg tie at Old Trafford.
The entire Tottenham squad looked a shadow of their former slick-passing, fast-moving selves in their 1-0 Europa League defeat at Gent on Thursday.