Antonio Conte has confirmed that John Terry and Branislav Ivanovic are fit to face West Ham in the EFL Cup fifth round while Willian is available.
Guardiola told a news conference: "Kevin has a knock and he cannot play... Vincent I think he can but I need to see training and regeneration."
This could be the most dreaded Manchester derbies in years with both United and City fans desperate for their respective sides to stop the rot.
The EFL Cup gives some Manchester United players the chance to impress Jose Mourinho against rivals Manchester City. Here's five who need to shine.
United are preparing to face City at Old Trafford in the EFL Cup fourth round on Wednesday, looking for a response after their 4-0 defeat at Chelsea.
Arsenal stormed back from a 4-0 deficit to win 7-5 after extra-time in 2012 with Theo Walcott scoring a hat trick.