Nani says Valencia will enjoy the challenge of facing Real Madrid, as they try to pull clear of the bottom teams in Spain.
Ramos, who left Sevilla for Madrid in 2005, saw his relationship with fans of his hometown club radically deteriorate earlier this year.
Paris Saint-Germain midfielder Blaise Matuidi has said that Barcelona legend Andres Iniesta sees Marco Verratti as the heir to his throne.
Skipper Ramos was absent against Espanyol after suffering a bang to his hip in the Champions League win over Napoli.
Barcelona's 4-0 defeat at Paris Saint-Germain in the Champions League last week has fuelled speculation that coach will not remain at the helm.
Schalke will sign winger Yevhen Konoplyanka on a permanent transfer from Sevilla, the Royal Blues' sporting executive Christian Heidel has confirmed.