The draw is due to take place from around midday GMT, 7 a.m. ET on Friday, Feb. 24.
Alex Pozuelo fired in a stunning free kick to seal Genk's progression past Astra into the Europa League last 16.
Nabil Fekir's hat trick highlighted Lyon's dominant 7-1 win over Alkmaar, as they cruised into the round of 16.
Tottenham's pair of star men suffered a meltdown on Thursday, as Spurs drew 2-2 with Gent at Wembley but lost 3-2 on aggregate in the Europa League.
Trailing 3-0 on aggregate, Borussia Monchengladbach stormed back with four unanswered goals to shock Fiorentina.
Vyacheslav Karavev finally put Sparta Prague on the scoreboard, but Rostov advance to the next round on 5-1 aggregate.