Liga MX club Pumas were up to the task at home on Thursday night, securing a 2-0 win against Honduras Progreso in CONCACAF Champions League Group A.
Arabe Unido ran out to an early 3-1 lead against Monterrey and never looked back, holding on to win 3-2.
Sporting Kansas City earned a point in its Group C opener of the CONCACAF Champions League, drawing 2-2 away to Central FC of Trinidad & Tobago.
FC Dallas dominated Real Esteli for 90 minutes but only managed a 2-1 victory in its Group H CONCACAF Champions League opener.
New York Red Bulls beat Antigua in its CONCACAF Champions League opener in Harrison, New Jersey, while Pumas were too much for W Connection FC.
Four teams will be looking to continue Liga MX's dominance over MLS in the CONCACAF Champions League. Arch Bell previews the 2016-17 CCL group stage.