Paul Pogba scored twice as Manchester United eased to a comfortable 4-0 Europa League victory against Fenerbahce at Old Trafford.
Pogba scored two of United's four and Robin van Persie scored Fenerbahce's consolation goal in his return to Old Trafford.
Southampton manager Claude Puel dismissed suggestions his rotation system was responsible for their "unlucky" 1-0 Europa League defeat at Inter Milan.
Alassane Plea's first-half strike handed Nice their first ever European away victory as they secured a 1-0 Europa League win over Salzburg.
Standard Liège came back from 0-2 down to draw 2-2 with Panathinaikos, in Group G.
Southampton's Virgil van Dijk said Southampton should have put the game away easily in the first half.