Dani Carvajal has been ruled out of action with a heart problem, with Marca reporting that the Real Madrid defender could be out of action for up to six weeks.
Carvajal will not be in the Madrid squad to take on Espanyol at the Bernabeu on Sunday, with a club statement saying he "has been diagnosed with a viral pericardium infection."
The statement said the full-back's "recovery will continue to be assessed."
He has previously played every minute for Zinedine Zidane's side in La Liga this season, and the setback means he drops out of the Spain squad for the World Cup qualifiers against Albania and Israel.
Earlier this month, Carvajal signed a two-year contract extension and said he would be "delighted" to be Real Madrid captain in the future.
The 25-year-old said: "I'm very grateful to the club. I've been fortunate to win every title with Real Madrid, and I'm looking forward to winning them again.
"I would like that. the day that I leave, everyone knows that I have given everything for this club and that they are proud."
Following the club's 2-0 defeat of Espanyol on Sunday, Zidane suggested the condition was not as serious an issue as it sounds.
"Dani will not go with the national team this week," Zidane said. "We will see how he recovers. It is not anything dangerous, but he will remain here with us."