Markel Susaeta has been handed his first call-up to the Spain squad for the Nov. 14 friendly in Panama.
The Athletic Bilbao midfielder is a surprise inclusion in Vicente del Bosque's side, but has been given his chance following a series of impressive performances at club level.
Barcelona defender Martin Montoya has been called up for the second time. He was an unused member of the Spain squad which faced Chile in a friendly last September.
Montoya is one of eight Barca players in the line-up, although Xavi has been rested for this match along with Real Madrid midfielder Xabi Alonso.
Chelsea striker Juan Mata returns after missing the World Cup qualifiers against Belarus and France, but club teammate Fernando Torres has been left out.
There is no place for Liverpool goalkeeper Jose Reina either.
The Spain squad for the friendly against Panama on Nov. 14 follows: Valdes (Barcelona), Casillas (Real Madrid); Montoya (Barcelona), Ramos, Albiol (both Real Madrid), Alba (Barcelona), Juanfran (Atletico Madrid), Martinez (Bayern Munich); Iniesta, Fabregas, Busquets (all Barcelona), Cazorla (Arsenal), Benat (Real Betis); Villa (Barcelona), Susaeta (Athletic Bilbao), Pedro (Barcelona), Navas (Sevilla), Soldado (Valencia), Mata (Chelsea).