UEFA Cup holders Sevilla made a positive impact following their step up to Europe's elite club competition with victory over AEK Athens.
The Spanish hosts won the first leg of their Champions League third qualifying round tie 2-0 with goals from Luis Fabiano and ex-West Ham and Tottenham forward Frederic Kanoute.
Former winners Ajax have a mountain to climb against Slavia Prague after David Kalivoda's 76th-minute goal earned the Czechs a 1-0 victory in Amsterdam.
Fenerbahce will take a slender 1-0 lead into the return leg of their clash with Anderlecht thanks to Alex de Souza's decider, while Dynamo Kiev beat FK Sarajevo by the same scoreline following a goal from Maxim Shatskikh.
Rosenborg are also on course for a spot in the next round following a comprehensive 3-0 win over Finnish champions Tampere United.
Miika Koppinen got the ball rolling for the Norwegian visitors, with Ivory Coast striker Yssouf Kone adding a brace to secure a healthy advantage ahead of the second leg in Trondheim.
BATE Borisov and Steaua Bucharest played out a draw with Gennady Bliznuk's last-gasp goal securing a 2-2 draw for the Belarus title-holders.
Goals from Dorin Goian and Nicolae Dica had given Steaua a 2-1 lead following Artem Radkov's opener for the hosts.
Besiktas scored a valuable away goal to claim a 1-1 draw at Swiss champions FC Zurich.
But it could have been even better for the Turkish giants, who opened the scoring through Matias Delgado after just three minutes before Alexandre Alphonse snatched a last-minute equaliser.
Shakhtar Donetsk have some work to do in the second leg in Ukraine after Alexander Zickler's penalty earned SV Salzburg a 1-0 win.
Werder Bremen battled back from a goal down to see off Dinamo Zagreb 2-1 at the Weserstadion thanks to Hugo Almeida and Daniel Jensen.
Bosko Balaban had fired the Croatian visitors ahead two minutes before the interval.