Jose Mourinho is set to rest David De Gea, Nemanja Matic, Ashley Young and Phil Jones in Manchester United's Carabao Cup quarterfinal at Bristol City on Wednesday.
United have a run of five games in 14 days following their trip to Ashton Gate and Mourinho has taken the opportunity to give four senior players the night off.
Henrikh Mkhitaryan is set to feature after the Armenia midfielder was omitted from eight of the last nine matchday squads.
Paul Pogba will also make his return after serving a three-game suspension.
Antonio Valencia has been added to an injury list that already included Eric Bailly and Marouane Fellaini after the right-back limped off with a hamstring injury during the 2-1 win at West Bromwich Albion on Sunday.
Manchester City and Arsenal have already booked their places in the semifinals, the draw for which will take place on Wednesday night.
They could be joined by United and Chelsea, who face Bournemouth at Stamford Bridge.
United are defending the trophy they won last season, and Marcos Rojo said the competition was a priority for Mourinho and his squad.
He told MUTV: "People talk about this trophy, saying it is not important, but when you have had the experience of getting a long way in the competition and eventually winning it, everyone wants to do it again.
"I think it is important, even though we are away from home, that we go there really positive and try to take the game to them, impose ourselves on the game and try to dominate proceedings from the word go.
"Hopefully, by imposing our style, we can come away with a victory that we need."