Gonzalo Higuain reached 32 goals for the season as Napoli held onto second place in the Serie A table by beating Atalanta 2-1 at the Stadio San Paolo.
The league's leading scorer notched either side of the break to prevent Roma from moving into the runners-up spot, with Raul Albiol putting through his own net to give the southerners the jitters at the death.
After some probing by both sides the ball fell nicely for Marek Hamsik, who cut inside from the left to supply Higuain for his 31st goal in 32 matches.
Higuain further extended his tally by turning Jose Callejon's cross beyond Sportiello to rubber-stamp the three points.
It was just as well the Argentinian had bagged a brace, as Albiol spoiled Napoli's clean sheet five minutes from time, the former Real Madrid defender accidentally turning Kalidou Koulibaly's attempted clearance over the line.
Substitute Francesco Totti once again inspired Roma to a dramatic late victory as the Giallorossi rallied to beat Genoa 3-2 at the Stadio Luigi Ferraris.
The 39-year-old striker had scored three key goals from the bench in recent matches and further strengthened his claim for a new contract with the capital club by notching from the bench in Genoa and inspiring Stephan El Shaarawy to plunder a last-gasp winner.
Mohamed Salah's early goal had been cancelled out by Panagiotis Tachtsidis before Leonardo Pavoletti briefly fired Genoa into the lead. That, however, was Totti's cue to come to the party.
Totti came on the pitch at the hour mark but waited until the 77th minute to make his presence felt. From a long-range free kick, the evergreen forward rasped the ball over Lamanna's shoulder to level the tie.
Encouraged by their veteran teammate, Roma pushed hard for the winner and found it through El Shaarawy three minutes from time. Edin Dzeko supplied the through ball and Lamanna was soon bested by a powerful effort for the third time in the match.