Roma picked up their first win of the new season on Sunday at the Stadio Olimpico with a 2-1 victory over 10-man Juventus to send the defending champions crashing to a second straight defeat.
Miralem Pjanic, denied by the post in the opening half, gave the hosts a deserved lead with a powerful free-kick in the 61st minute.
After Juve had Patrice Evra sent off for a second yellow card with 12 minutes remaining, Roma made them pay seconds later when Manchester City's on-loan striker Edin Dzeko headed in Iago Falque's cross for his first Serie A goal.
Paulo Dybala reduced the arrears with three minutes remaining but Juve did not find the equaliser despite having chances to do so.
Stevan Jovetic's late penalty handed Inter Milan a 2-1 win at newly-promoted Carpi.
Carpi looked to be heading for a 1-1 draw in their first ever Serie A game at home after substitute Antonio Di Gaudio cancelled out Jovetic's opener with nine minutes remaining.
However, after Carpi's Gabriel Silva brought down Fredy Guarin inside the area, Jovetic, an on-loan striker from Manchester City, came to the rescue for a second successive game by converting from the penalty spot one minute from time.
The win allowed Inter to maintain a 100 percent record after their 1-0 triumph over Atalanta in their opener, which was also courtesy of Jovetic's winner.
Carpi, meanwhile, are still searching for their first point after their 5-2 defeat at Sampdoria on their debut.
Chievo produced a convincing performance at home and beat Lazio 4-0 to pick up their second win of the season.
Riccardo Meggiorini put the hosts on their way in the 12th minute before Alberto Paloschi doubled the advantage on the half-hour mark.
Valter Birsa made it 3-0 on the stroke of half-time and Paloschi added his second of the evening in the 68th minute to cap off a wonderful evening for the Verona outfit.
The victory has lifted Chievo to the top of the standings, level on six points with Torino, Inter, Sassuolo and Palermo two games into the season.
Torino struck three times in the space of 10 minutes to clinch a 3-1 come-from-behind victory over Fiorentina in Turin.
Marcos Alonso put the visitors ahead in the 10th minute but the hosts hit back after the restart with goals from Emiliano Moretti, Fabio Quagliarella and Daniele Baselli to seal the win.
The victory, Toro's second straight following their 2-1 win at Frosinone last week, has lifted the Granata to second place in the standings, level on six points with Chievo, Inter Milan, Sassuolo and Palermo.
Napoli's winless run continued as the azzurri threw away a 2-0 lead to settle for a 2-2 draw against Sampdoria.
Gonzalo Higuain struck twice to give the hosts a commanding first-half lead.
However, Citadin Eder came to the rescue for Samp by scoring two goals in the space of two minutes to earn his team a valuable point at the San Paolo stadium and deny the hosts their first victory of the campaign.
Luca Rigoni scored the only goal of the game as 10-man Palermo upset Udinese 1-0 at the Friuli stadium to pick up their second straight win in Serie A.
The Italian midfielder put the visitors ahead in the eighth minute and despite being reduced to 10 men from the 70th minute after defender Aljaz Struna was shown his second yellow card, the Sicilians held on for victory.
Genoa produced a convincing performance at home to Hellas Verona to pick up their first win of the season.
Second-half goals from substitute Leonardo Pavoletti and summer signing Serge Gakpe ensured a 2-0 success and the first points of the season for hosts.
Atalanta picked up their first points of the new season with a 2-0 victory over promoted Frosinone in Bergamo on Sunday evening.
Goals from Guglielmo Stendardo and Alejandro Gomez in each half handed the Bergamaschi a deserved win.
Defeat leaves Serie A new boys Frosinone without a point from their first two games of the campaign.